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Thirty Years' War. The Thirty Years' War, [j] from 1618 to 1648, was one of the most destructive conflicts in European history. Fought primarily in Central Europe, an estimated 4.5 to 8 million soldiers and civilians died from the effects of battle, famine, or disease, while parts of Germany reported population declines of over 50%. [19]
Trisomy 21. Down syndrome (also known by the karyotype 47,XX,+21 for females and 47,XY,+21 for males) [98] is mostly caused by a failure of the 21st chromosome to separate during egg or sperm development, known as nondisjunction. [91] As a result, a sperm or egg cell is produced with an extra copy of chromosome 21; this cell thus has 24 ...
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